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Target
Putative hydrolase
Ligand
BDBM50385105
Substrate
n/a
Meas. Tech.
Biochemical Characterization of Cif Inhibitors
IC50
2700±400 nM
Citation
 Madden, DR; Bahl, CD; Hammock, BD; Morisseau, C Compounds and methods for inhibiting Cif virulence factor US Patent  US10322118 Publication Date 6/18/2019 
Target
Name:
Putative hydrolase
Synonyms:
CFTR inhibitory factor, Cif | Putative hydrolase | cif
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35786.52
Organism:
Pseudomonas aeruginosa (strain UCBPP-PA14)
Description:
A0A0H2ZD27
Residue:
319
Sequence:
MILDRLCRGLLAGIALTFSLGGFAAEEFPVPNGFESAYREVDGVKLHYVKGGQGPLVMLVHGFGQTWYEWHQLMPELAKRFTVIAPDLPGLGQSEPPKTGYSGEQVAVYLHKLARQFSPDRPFDLVAHDIGIWNTYPMVVKNQADIARLVYMEAPIPDARIYRFPAFTAQGESLVWHFSFFAADDRLAETLIAGKERFFLEHFIKSHASNTEVFSERLLDLYARSYAKPHSLNASFEYYRALNESVRQNAELAKTRLQMPTMTLAGGGHGGMGTFQLEQMKAYAEDVEGHVLPGCGHWLPEECAAPMNRLVIDFLSRGR
  
Inhibitor
Name:
BDBM50385105
Synonyms:
CHEMBL2035874 | US10322118, Entry 8b
Type:
Small organic molecule
Emp. Form.:
C18H17Br2NO5
Mol. Mass.:
487.139
SMILES:
CC(C)c1cc(Oc2c(Br)cc(NC(=O)CC(O)=O)cc2Br)ccc1O
Structure:
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