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Target
Serine/threonine-protein kinase D1
Ligand
BDBM32352
Substrate
Substrate Peptide
Meas. Tech.
Fluorescence polarization assay for PKD inhibitiors-IC50 determinations
pH
7.2±n/a
Temperature
296.15±n/a K
IC50
>50000±n/a nM
Citation
 PubChem, PC Fluorescence polarization assay for PKD inhibitiors-IC50 determinations PubChem Bioassay (2008)[AID] 
Target
Name:
Serine/threonine-protein kinase D1
Synonyms:
KPCD1_HUMAN | PKD | PKD1 | PRKCM | PRKD1 | Protein kinase C mu | Protein kinase C mu type | Protein kinase C mu type (PRKD1) | Protein kinase C, PKC; classical/novel | Protein kinase D | Protein kinase D (PRKD1) | Serine/threonine-protein kinase D1 (PKD1) | nPKC-D1 | nPKC-mu
Type:
Serine/threonine-protein kinase
Mol. Mass.:
101705.07
Organism:
Homo sapiens (Human)
Description:
gi_115529463
Residue:
912
Sequence:
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
  
Inhibitor
Name:
BDBM32352
Synonyms:
2-(3-besylpropanoylimino)-3,4-dimethyl-4-thiazoline-5-carboxylic acid ethyl ester | 2-[3-(benzenesulfonyl)-1-oxopropyl]imino-3,4-dimethyl-5-thiazolecarboxylic acid ethyl ester | MLS000624279 | SMR000323584 | cid_7243149 | ethyl 2-[3-(benzenesulfonyl)propanoylimino]-3,4-dimethyl-1,3-thiazole-5-carboxylate | ethyl 3,4-dimethyl-2-[3-(phenylsulfonyl)propanoylimino]-1,3-thiazole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H20N2O5S2
Mol. Mass.:
396.481
SMILES:
CCOC(=O)c1sc(=NC(=O)CCS(=O)(=O)c2ccccc2)n(C)c1C |w:8.8|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Substrate Peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
ATP as co-substrate
Residue:
3
Sequence:
NA