Reaction Details Report a problem with these data
Target
Plasmepsin IV
Ligand
BDBM32386
Substrate
Plasmepsin Substrate Peptide
Meas. Tech.
Enzyme Inhibition Assay
pH
4.5±n/a
Temperature
296.15±n/a K
Ki
42000±n/a nM
Km
28000±n/a nM
Citation
 Blum, A; Böttcher, J; Sammet, B; Luksch, T; Heine, A; Klebe, G; Diederich, WE Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors. Bioorg Med Chem 16:8574-86 (2008) [PubMed]  Article 
Target
Name:
Plasmepsin IV
Synonyms:
PLM4_PLAF7 | PMIV
Type:
Enzyme
Mol. Mass.:
51038.16
Organism:
Plasmodium falciparum
Description:
Q8IM16
Residue:
449
Sequence:
MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGNFYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYLGSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSEFDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYEGPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKVPFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTFILGDPFMRKYFTVFDYEKESVGFAVAKNL
  
Inhibitor
Name:
BDBM32386
Synonyms:
phenyl-substituted sulfonamides, 6c
Type:
Small organic molecule
Emp. Form.:
C32H37N3O4S2
Mol. Mass.:
591.784
SMILES:
O=S(=O)(N(CCCNCCCN(Cc1ccccc1)S(=O)(=O)c1ccccc1)Cc1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Plasmepsin Substrate Peptide
Synonyms:
n/a
Type:
fluorogenic substrate
Mol. Mass.:
2590.28
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
ATHRILENLEPNPHEGLNARGNH