Reaction Details Report a problem with these data
Target
Baculoviral IAP repeat-containing protein 3 [255-322]
Ligand
BDBM32580
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements
pH
7.2±n/a
Temperature
295.15±n/a K
Ki
85±n/a nM
Citation
 Ndubaku, C; Varfolomeev, E; Wang, L; Zobel, K; Lau, K; Elliott, LO; Maurer, B; Fedorova, AV; Dynek, JN; Koehler, M; Hymowitz, SG; Tsui, V; Deshayes, K; Fairbrother, WJ; Flygare, JA; Vucic, D Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists. ACS Chem Biol 4:557-66 (2009) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 3 [255-322]
Synonyms:
API2 | Apoptosis inhibitor 2 | BIRC3 | BIRC3_HUMAN | Baculoviral IAP repeat-containing protein 3 | Inhibitor of apoptosis protein 1 | MIHC | RNF49 | cIAP-2 BIR3
Type:
BIR3 domain
Mol. Mass.:
7852.71
Organism:
Homo sapiens (Human)
Description:
Q13489[255-322]
Residue:
68
Sequence:
HAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYL
  
Inhibitor
Name:
BDBM32580
Synonyms:
CS-3
Type:
Small organic molecule
Emp. Form.:
C28H38N6O3
Mol. Mass.:
506.6397
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CC[C@H](C)[C@H]1C(=O)Nc1ccccc1-c1ncccn1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17342
Synonyms:
5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
Type:
Fluorescent dye-conjugated peptide
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: