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Target
Prolyl hydroxylase EGLN3
Ligand
BDBM107698
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
180±n/a nM
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent  USRE47437 Publication Date 6/18/2019 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM107698
Synonyms:
US11426393, Compound Table XV.4 | US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy-5-(4-methylphenyl)pyridine-2- carbonyl)amino]-acetic acid | US9598370, Example 00129 | USRE47437, Example [(3-Hydroxy-5-(4-methylphenyl)pyridine-2-carbonyl)amino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C15H14N2O4
Mol. Mass.:
286.2827
SMILES:
Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Structure:
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