Reaction Details Report a problem with these data
Target
Sodium/bile acid cotransporter
Ligand
BDBM400082
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
1.80±n/a nM
Citation
 Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ Substituted pyrrolizine compounds and uses thereof US Patent  US10328053 Publication Date 6/25/2019 
Target
Name:
Sodium/bile acid cotransporter
Synonyms:
Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1
Type:
PROTEIN
Mol. Mass.:
38131.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_838517
Residue:
349
Sequence:
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
  
Inhibitor
Name:
BDBM400082
Synonyms:
N-(3-chloro-4-fluorophenyl)-7-(2-((1-ethynyl-3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide | US10328053, Compound 60 | US10874640, Compound 60 | US20230270719, Compound 60
Type:
Small organic molecule
Emp. Form.:
C23H19ClF3N3O3
Mol. Mass.:
477.863
SMILES:
Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C#C)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Structure:
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