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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM11835
Substrate
PIM substrate p21
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1800±n/a nM
Citation
 Pogacic, V; Bullock, AN; Fedorov, O; Filippakopoulos, P; Gasser, C; Biondi, A; Meyer-Monard, S; Knapp, S; Schwaller, J Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. Cancer Res 67:6916-24 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM11835
Synonyms:
1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]pyridazin-3-yl}phenyl)ethan-1-one | CHEMBL200528 | Cancer Res 676916 Compound K00135 | Imidazol[1,2-b]pyridazine 1
Type:
Small organic molecule
Emp. Form.:
C18H18N4O
Mol. Mass.:
306.3617
SMILES:
CC(=O)c1cccc(c1)-c1cnc2ccc(NCC3CC3)nn12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
PIM substrate p21
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1281.47
Organism:
n/a
Description:
n/a
Residue:
10
Sequence:
RKRRQTSMTD