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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM35053
Substrate
PIM substrate p21
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2500±n/a nM
Citation
 Pogacic, V; Bullock, AN; Fedorov, O; Filippakopoulos, P; Gasser, C; Biondi, A; Meyer-Monard, S; Knapp, S; Schwaller, J Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. Cancer Res 67:6916-24 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM35053
Synonyms:
K00486
Type:
Small organic molecule
Emp. Form.:
C16H16ClFN4O
Mol. Mass.:
334.776
SMILES:
CCC(CO)Nc1ccc2ncc(-c3ccc(F)c(Cl)c3)n2n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
PIM substrate p21
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1281.47
Organism:
n/a
Description:
n/a
Residue:
10
Sequence:
RKRRQTSMTD