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Target
Interferon-induced, double-stranded RNA-activated protein kinase
Ligand
BDBM308051
Substrate
n/a
Meas. Tech.
KinaseGlo Assay
IC50
39.0±n/a nM
Citation
 Boral, S; Malone, TC; Wang, S; Rao, S; Yang, R Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors US Patent  US10011593 Publication Date 7/3/2018 
Target
Name:
Interferon-induced, double-stranded RNA-activated protein kinase
Synonyms:
Eukaryotic translation initiation factor 2-alpha kinase 2 | eIF-2A protein kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | Protein kinase RNA-activated | Protein kinase R | Tyrosine-protein kinase EIF2AK2 | p68 kinase | E2AK2_HUMAN | EIF2AK2 | PKR | PRKR
Type:
PROTEIN
Mol. Mass.:
62104.61
Organism:
Human
Description:
ChEMBL_1467743
Residue:
551
Sequence:
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSGSFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC
  
Inhibitor
Name:
BDBM308051
Synonyms:
US9650366, 3 | US10011593, Ex. 3
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Structure:
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