Reaction Details Report a problem with these data
Target
Splicing factor 3B subunit 3
Ligand
BDBM36360
Substrate
n/a
Meas. Tech.
VEGF-PLAP
pH
7.8±0
Temperature
277.15±0 K
EC50
4.9±0.0 nM
Citation
 Kotake, Y; Sagane, K; Owa, T; Mimori-Kiyosue, Y; Shimizu, H; Uesugi, M; Ishihama, Y; Iwata, M; Mizui, Y Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol 3:570-5 (2007) [PubMed]  Article 
Target
Name:
Splicing factor 3B subunit 3
Synonyms:
KIAA0017 | SAP130 | SF3B3 | SF3B3_HUMAN
Type:
PROTEIN
Mol. Mass.:
135544.53
Organism:
Homo sapiens (Human)
Description:
Q15393
Residue:
1217
Sequence:
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF
  
Inhibitor
Name:
BDBM36360
Synonyms:
CID16202133 | Pladienolide analog 8
Type:
Small organic molecule
Emp. Form.:
C31H51NO8
Mol. Mass.:
565.7385
SMILES:
CCNC(=O)O[C@H]1\C=C\[C@H](C)[C@H](OC(=O)C[C@H](O)CC[C@@]1(C)O)C(\C)=C\C=C\[C@@H](C)C[C@H]1O[C@@H]1[C@H](C)[C@@H](O)CC |t:7|
Structure:
Search PDB for entries with ligand similarity: