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Target
Uracil-DNA glycosylase
Ligand
BDBM36455
Substrate
BDBM36458
Meas. Tech.
UNG Inhibition Assay
pH
8±0
IC50
3.15e+5±n/a nM
Citation
 Chung, S; Parker, JB; Bianchet, M; Amzel, LM; Stivers, JT Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nat Chem Biol 5:407-13 (2009) [PubMed]  Article 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
DGU | UDG | UNG | UNG1 | UNG15 | UNG_HUMAN | Uracil-DNA glycosylase (UNG)
Type:
Protein
Mol. Mass.:
34661.15
Organism:
Homo sapiens (Human)
Description:
P1305
Residue:
313
Sequence:
MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGTPPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKTNELLQKSGKKPIDWKEL
  
Inhibitor
Name:
BDBM36455
Synonyms:
6-[4-[(3-Carboxybenzylamino)butylamino]methyl]uracil, 27 | CID25210542
Type:
Small organic molecule
Emp. Form.:
C17H22N4O4
Mol. Mass.:
346.381
SMILES:
OC(=O)c1cccc(CNCCCCNCc2cc(=O)[nH]c(=O)[nH]2)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM36458
Synonyms:
6-Formyluracil, 11 | CID70951
Type:
Substrate
Emp. Form.:
C5H4N2O3
Mol. Mass.:
140.0969
SMILES:
O=Cc1cc(=O)[nH]c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: