Reaction Details
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Aurora kinase A
Ligand
BDBM36470
Substrate
n/a
Meas. Tech.
Aurora A Inhibition Assay
pH
9.5±0
Temperature
289.15±0 K
IC50
2.7e+2±n/a nM
Citation
Clark, MA; Acharya, RA; Arico-Muendel, CC; Belyanskaya, SL; Benjamin, DR; Carlson, NR; Centrella, PA; Chiu, CH; Creaser, SP; Cuozzo, JW; Davie, CP; Ding, Y; Franklin, GJ; Franzen, KD; Gefter, ML; Hale, SP; Hansen, NJ; Israel, DI; Jiang, J; Kavarana, MJ; Kelley, MS; Kollmann, CS; Li, F; Lind, K; Mataruse, S; Medeiros, PF; Messer, JA; Myers, P; O'Keefe, H; Oliff, MC; Rise, CE; Satz, AL; Skinner, SR; Svendsen, JL; Tang, L; van Vloten, K; Wagner, RW; Yao, G; Zhao, B; Morgan, BA Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat Chem Biol 5:647-54 (2009) [PubMed] Article More Info.:
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Inhibitor
Name:
BDBM36470
Synonyms:
2-(4-(3,4-Dimethoxyphenylamino)-6-(quinolin-6-ylamino)-1,3,5-triazin-2-ylamino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanamide | DEL-A, 11
Type:
Small organic molecule
Emp. Form.:
C30H28N10O3
Mol. Mass.:
576.6085
SMILES:
COc1ccc(Nc2nc(NC(Cc3c[nH]c4ncccc34)C(N)=O)nc(Nc3ccc4ncccc4c3)n2)cc1OC
Structure:
