Reaction Details Report a problem with these data
Target
m7GpppX diphosphatase
Ligand
BDBM36533
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
9.38±0.0 nM
EC50
108±0.0 nM
Citation
 Singh, J; Salcius, M; Liu, SW; Staker, BL; Mishra, R; Thurmond, J; Michaud, G; Mattoon, DR; Printen, J; Christensen, J; Bjornsson, JM; Pollok, BA; Kiledjian, M; Stewart, L; Jarecki, J; Gurney, ME DcpS as a therapeutic target for spinal muscular atrophy. ACS Chem Biol 3:711-22 (2008) [PubMed]  Article 
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Homo sapiens (Human)
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
  
Inhibitor
Name:
BDBM36533
Synonyms:
D157555
Type:
Small organic molcule
Emp. Form.:
C19H25N7O
Mol. Mass.:
367.4481
SMILES:
Cn1ccnc1CN1CCC(COc2cccc3nc(N)nc(N)c23)CC1
Structure:
Search PDB for entries with ligand similarity: