Reaction Details
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Report a problem with these dataTarget
Methionine aminopeptidase 2
Ligand
BDBM36592
Substrate
n/a
Meas. Tech.
Proliferation Assay
pH
7.5±0
EC50
0.12±0.01 nM
Citation
Griffith, EC; Su, Z; Turk, BE; Chen, S; Chang, YH; Wu, Z; Biemann, K; Liu, JO Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol 4:461-71 (1997) [PubMed] Article More Info.:
Target
Name:
Methionine aminopeptidase 2
Synonyms:
MAP2_MOUSE | Metap2 | Methionine aminopeptidase Type 2 (MetAP2) | Mnpep | P67eif2 | Peptidase M 2
Type:
Enzyme
Mol. Mass.:
52914.64
Organism:
Mus musculus (Mouse)
Description:
O08663
Residue:
478
Sequence:
MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
Inhibitor
Name:
BDBM36592
Synonyms:
FOS-70
Type:
Small organic molecule
Emp. Form.:
C20H31ClO5
Mol. Mass.:
386.91
SMILES:
[#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6]-1[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#6]-[#6]-[#6]Cl |r|
Structure:
