Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM36829
Substrate
n/a
Meas. Tech.
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR
EC50
32150±n/a nM
Citation
 PubChem, PC Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM36829
Synonyms:
5-Phenyl-7-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidine | 5-phenyl-7-[4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]-[1,2,4]triazolo[1,5-a]pyrimidine | 5-phenyl-7-[4-[5-(trifluoromethyl)-2-pyridyl]piperazino]-[1,2,4]triazolo[1,5-a]pyrimidine | 5-phenyl-7-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidine | MLS000035358 | SMR000008093 | cid_646427
Type:
Small organic molecule
Emp. Form.:
C21H18F3N7
Mol. Mass.:
425.4097
SMILES:
FC(F)(F)c1ccc(nc1)N1CCN(CC1)c1cc(nc2ncnn12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: