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Target
Serine/threonine-protein kinase B-raf [409-765]
Ligand
BDBM185588
Substrate
n/a
Meas. Tech.
RAF Kinase Activity
IC50
42.0±n/a nM
Citation
 Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases US Patent  USRE47451 Publication Date 6/25/2019 
Target
Name:
Serine/threonine-protein kinase B-raf [409-765]
Synonyms:
B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
COOH-terminal kinase domain
Mol. Mass.:
40238.92
Organism:
Homo sapiens (Human)
Description:
Recombinant baculoviruses expressing B-RAF (residues 409-765) was purified as a fusion protein.
Residue:
357
Sequence:
SLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPV
  
Inhibitor
Name:
BDBM185588
Synonyms:
US9156852, 59 | USRE47451, Example 59
Type:
Small organic molecule
Emp. Form.:
C26H24ClN7OS
Mol. Mass.:
518.033
SMILES:
CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl
Structure:
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