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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM32663
Substrate
n/a
Meas. Tech.
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Parental Cell Line Counter Screen 60K MLSMR
EC50
5750±n/a nM
Citation
 PubChem, PC Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Parental Cell Line Counter Screen 60K MLSMR PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM32663
Synonyms:
2,3-Dihydro-benzo[1,4]dioxine-6-sulfonic acid [1-(4-p-tolyl-thiazol-2-yl)-piperidin-4-yl]-amide | MLS000068112 | N-[1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]piperidin-4-yl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamide | N-[1-[4-(4-methylphenyl)-2-thiazolyl]-4-piperidinyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide | N-[1-[4-(p-tolyl)thiazol-2-yl]-4-piperidyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide | SMR000000949 | cid_650250
Type:
Small organic molecule
Emp. Form.:
C23H25N3O4S2
Mol. Mass.:
471.592
SMILES:
Cc1ccc(cc1)-c1csc(n1)N1CCC(CC1)NS(=O)(=O)c1ccc2OCCOc2c1
Structure:
Search PDB for entries with ligand similarity: