Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM38311
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
9970.4±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM38311
Synonyms:
3,3-dimethyl-6-(2-oxolanylmethylamino)-8-propan-2-yl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile | 3,3-dimethyl-6-(oxolan-2-ylmethylamino)-8-propan-2-yl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile | 8-isopropyl-3,3-dimethyl-6-(tetrahydrofurfurylamino)-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile | MLS000030457 | SMR000039337 | cid_658465
Type:
Small organic molecule
Emp. Form.:
C19H27N3O2
Mol. Mass.:
329.4366
SMILES:
CC(C)c1nc(NCC2CCCO2)c(C#N)c2CC(C)(C)OCc12
Structure:
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