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Target
Mevalonate kinase
Ligand
BDBM38612
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response
IC50
6871.6±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Mevalonate kinase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31420.64
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZQX9
Residue:
292
Sequence:
MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMAVYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLSAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEIAISQKDAEGLGQILSQAHLHLKEIGVSSLEADSLVETALSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL
  
Inhibitor
Name:
BDBM38612
Synonyms:
7-(5-chloro-2-methoxy-anilino)-6-p-anisyl-7H-pyrrolo[3,4-b]pyridin-5-one | 7-(5-chloro-2-methoxyanilino)-6-[(4-methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one | 7-[(5-chloranyl-2-methoxy-phenyl)amino]-6-[(4-methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one | 7-[(5-chloro-2-methoxyphenyl)amino]-6-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one | MLS000045769 | SMR000028166 | cid_3243170
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O3
Mol. Mass.:
409.866
SMILES:
COc1ccc(Cn2c(Nc3cc(Cl)ccc3OC)c3[nH]cccc3c2=O)cc1
Structure:
Search PDB for entries with ligand similarity: