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Target
Dual specificity protein phosphatase 1
Ligand
BDBM35373
Substrate
n/a
Meas. Tech.
In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of DTT
IC50
42086±n/a nM
Citation
 PubChem, PC In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of DTT PubChem Bioassay (2006)[AID] 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM35373
Synonyms:
1-butyl-2-[2-(2,4-dimethoxyphenyl)-2-oxidanylidene-ethyl]sulfanyl-benzimidazole-5-sulfonamide | 1-butyl-2-[2-(2,4-dimethoxyphenyl)-2-oxoethyl]sulfanylbenzimidazole-5-sulfonamide | 1-butyl-2-[[2-(2,4-dimethoxyphenyl)-2-keto-ethyl]thio]benzimidazole-5-sulfonamide | 1-butyl-2-[[2-(2,4-dimethoxyphenyl)-2-oxoethyl]thio]-5-benzimidazolesulfonamide | MLS000055142 | SMR000066776 | cid_2997788
Type:
Small organic molecule
Emp. Form.:
C21H25N3O5S2
Mol. Mass.:
463.57
SMILES:
CCCCn1c(SCC(=O)c2ccc(OC)cc2OC)nc2cc(ccc12)S(N)(=O)=O
Structure:
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