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Target
Bcl-2-related protein A1
Ligand
BDBM39119
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
IC50
1300±140 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM39119
Synonyms:
3-chloranyl-1-(3,4-dichlorophenyl)-4-piperidin-1-yl-pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(1-piperidinyl)pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(piperidino)-1H-pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-piperidin-1-ylpyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-piperidino-3-pyrroline-2,5-quinone | CHEMBL1271938 | MLS-0066990.0001 | cid_1180675
Type:
Small organic molecule
Emp. Form.:
C15H13Cl3N2O2
Mol. Mass.:
359.635
SMILES:
ClC1=C(N2CCCCC2)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1 |c:1|
Structure:
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