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Target
Alkaline phosphatase, germ cell type
Ligand
BDBM39795
Substrate
n/a
Meas. Tech.
Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase
IC50
18800±1710 nM
Citation
 PubChem, PC Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase PubChem Bioassay (2007)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM39795
Synonyms:
(5Z)-3-[(4,6-dimethyl-2-pyrimidinyl)amino]-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-4-thiazolidinone | (5Z)-3-[(4,6-dimethylpyrimidin-2-yl)amino]-5-(4-hydroxybenzylidene)-2-thioxo-thiazolidin-4-one | (5Z)-3-[(4,6-dimethylpyrimidin-2-yl)amino]-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | 3-[(4,6-dimethyl-2-pyrimidinyl)amino]-5-(4-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one | MLS000571736 | SMR000193748 | cid_2248574
Type:
Small organic molecule
Emp. Form.:
C16H14N4O2S2
Mol. Mass.:
358.438
SMILES:
Cc1cc(C)nc(NN2C(=S)SC(=Cc3ccc(O)cc3)C2=O)n1 |w:13.13|
Structure:
Search PDB for entries with ligand similarity: