Reaction Details Report a problem with these data
Target
14-3-3 protein gamma
Ligand
BDBM39868
Substrate
n/a
Meas. Tech.
14-3-3 protein interaction modulators Dose Response Confirmation
IC50
>50000±n/a nM
Citation
 PubChem, PC 14-3-3 protein interaction modulators Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
14-3-3 protein gamma
Synonyms:
1433G_HUMAN | YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28289.17
Organism:
Homo sapiens (Human)
Description:
gi_21464101
Residue:
247
Sequence:
MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
  
Inhibitor
Name:
BDBM39868
Synonyms:
(5E)-1-(4-ethoxyphenyl)-5-[(2-piperazin-1-ylethylamino)methylidene]-1,3-diazinane-2,4,6-trione | (5E)-1-(4-ethoxyphenyl)-5-[[2-(1-piperazinyl)ethylamino]methylidene]-1,3-diazinane-2,4,6-trione | (5E)-5-[(2-piperazinoethylamino)methylene]-1-p-phenetyl-barbituric acid | MLS000036642 | SMR000057873 | cid_5389200
Type:
Small organic molecule
Emp. Form.:
C19H25N5O4
Mol. Mass.:
387.4329
SMILES:
CCOc1ccc(cc1)-n1c(O)c(C=NCCN2CCNCC2)c(=O)[nH]c1=O |w:14.15|
Structure:
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