Reaction Details Report a problem with these data
Target
14-3-3 protein gamma
Ligand
BDBM39878
Substrate
n/a
Meas. Tech.
14-3-3 protein interaction modulators Dose Response Confirmation
IC50
>50000±n/a nM
Citation
 PubChem, PC 14-3-3 protein interaction modulators Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
14-3-3 protein gamma
Synonyms:
1433G_HUMAN | YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28289.17
Organism:
Homo sapiens (Human)
Description:
gi_21464101
Residue:
247
Sequence:
MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
  
Inhibitor
Name:
BDBM39878
Synonyms:
2-(4-ethoxyphenyl)-6,7-dimethoxy-4-(4-methylpiperazin-1-yl)carbonyl-isoquinolin-1-one | 2-(4-ethoxyphenyl)-6,7-dimethoxy-4-(4-methylpiperazine-1-carbonyl)isoquinolin-1-one | 2-(4-ethoxyphenyl)-6,7-dimethoxy-4-[(4-methyl-1-piperazinyl)-oxomethyl]-1-isoquinolinone | 2-(4-ethoxyphenyl)-6,7-dimethoxy-4-[(4-methylpiperazin-1-yl)carbonyl]isoquinolin-1(2H)-one | 6,7-dimethoxy-4-(4-methylpiperazine-1-carbonyl)-2-p-phenetyl-isocarbostyril | MLS000086367 | SMR000021869 | cid_3240756
Type:
Small organic molecule
Emp. Form.:
C25H29N3O5
Mol. Mass.:
451.5149
SMILES:
CCOc1ccc(cc1)-n1cc(C(=O)N2CCN(C)CC2)c2cc(OC)c(OC)cc2c1=O
Structure:
Search PDB for entries with ligand similarity: