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Target
Ubiquitin carboxyl-terminal hydrolase BAP1
Ligand
BDBM39909
Substrate
n/a
Meas. Tech.
BAP1 Enzyme inhibitors Dose Response Confirmation
IC50
10487.3±n/a nM
Citation
 PubChem, PC BAP1 Enzyme inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms:
BAP1 | BAP1_HUMAN | KIAA0272 | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) (Cerebral protein 6).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80364.15
Organism:
Homo sapiens (Human)
Description:
gi_68565074
Residue:
729
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
  
Inhibitor
Name:
BDBM39909
Synonyms:
MLS000029781 | N-(3-Cyano-4,5-dimethyl-thiophen-2-yl)-2-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-acetamide | N-(3-cyano-4,5-dimethyl-2-thienyl)-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetamide | N-(3-cyano-4,5-dimethyl-2-thiophenyl)-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetamide | N-(3-cyano-4,5-dimethyl-thiophen-2-yl)-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanamide | N-(3-cyano-4,5-dimethylthiophen-2-yl)-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide | SMR000001725 | cid_656163
Type:
Small organic molecule
Emp. Form.:
C17H13FN4O2S2
Mol. Mass.:
388.439
SMILES:
Cc1sc(NC(=O)CSc2nnc(o2)-c2ccc(F)cc2)c(C#N)c1C
Structure:
Search PDB for entries with ligand similarity: