Reaction Details Report a problem with these data
Target
Mothers against decapentaplegic homolog 3
Ligand
BDBM40306
Substrate
n/a
Meas. Tech.
SMAD Transcription Factor Inhibitors Dose Response Confirmation
IC50
2300±n/a nM
Citation
 PubChem, PC SMAD Transcription Factor Inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Mothers against decapentaplegic homolog 3
Synonyms:
MADH3 | SMAD3 | SMAD3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48085.78
Organism:
Homo sapiens (Human)
Description:
gi_5174513
Residue:
425
Sequence:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
  
Inhibitor
Name:
BDBM40306
Synonyms:
5-(4,4-dimethyl-2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)-5-oxidanyl-1,3-diazinane-2,4,6-trione | 5-hydroxy-5-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexenyl)-1,3-diazinane-2,4,6-trione | 5-hydroxy-5-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-1,3-diazinane-2,4,6-trione | 5-hydroxy-5-(2-hydroxy-6-keto-4,4-dimethyl-cyclohexen-1-yl)barbituric acid | MLS000054954 | SMR000065773 | cid_2998967
Type:
Small organic molecule
Emp. Form.:
C12H14N2O6
Mol. Mass.:
282.2494
SMILES:
CC1(C)CC(=O)C(C(=O)C1)C1(O)C(=O)NC(=O)NC1=O
Structure:
Search PDB for entries with ligand similarity: