Reaction Details Report a problem with these data
Target
Mothers against decapentaplegic homolog 3
Ligand
BDBM40307
Substrate
n/a
Meas. Tech.
SMAD Transcription Factor Inhibitors Dose Response Confirmation
IC50
11110±n/a nM
Citation
 PubChem, PC SMAD Transcription Factor Inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Mothers against decapentaplegic homolog 3
Synonyms:
MADH3 | SMAD3 | SMAD3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48085.78
Organism:
Homo sapiens (Human)
Description:
gi_5174513
Residue:
425
Sequence:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
  
Inhibitor
Name:
BDBM40307
Synonyms:
MLS000046472 | N-(3-azepan-1-ylpropyl)-1-[2-(4-methylphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide | N-[3-(1-azepanyl)propyl]-1-[2-(4-methylphenyl)ethyl]-5-oxo-3-pyrrolidinecarboxamide | N-[3-(azepan-1-yl)propyl]-1-[2-(4-methylphenyl)ethyl]-5-oxidanylidene-pyrrolidine-3-carboxamide | N-[3-(azepan-1-yl)propyl]-1-[2-(4-methylphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide | N-[3-(azepan-1-yl)propyl]-5-keto-1-[2-(p-tolyl)ethyl]pyrrolidine-3-carboxamide | SMR000032483 | cid_3237466
Type:
Small organic molecule
Emp. Form.:
C23H35N3O2
Mol. Mass.:
385.5429
SMILES:
Cc1ccc(CCN2CC(CC2=O)C(=O)NCCCN2CCCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: