Reaction Details Report a problem with these data
Target
Coagulation factor XII
Ligand
BDBM33441
Substrate
n/a
Meas. Tech.
Factor XIIa Dose Response Confirmation
IC50
12529.52±659.855997 nM
Citation
 PubChem, PC Factor XIIa Dose Response Confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Coagulation factor XII
Synonyms:
Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Carboxylesterase 2 (intestine, liver) | Coagulation factor XII | Coagulation factor XII (FXII) | Coagulation factor XIIa heavy chain | Coagulation factor XIIa light chain | F12 | FA12_HUMAN | Factor XIIa | Factor XIIa (fXIIa) | HAF | Hageman factor
Type:
Enzyme
Mol. Mass.:
67810.07
Organism:
Homo sapiens (Human)
Description:
P00748
Residue:
615
Sequence:
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
  
Inhibitor
Name:
BDBM33441
Synonyms:
(5-amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(furan-2-yl)methanone | (5-azanyl-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(furan-2-yl)methanone | 1-(2-furoyl)-3-(3-pyridinyl)-1H-1,2,4-triazol-5-amine | MLS000064561 | SMR000077158 | [5-amino-3-(3-pyridinyl)-1,2,4-triazol-1-yl]-(2-furanyl)methanone | [5-amino-3-(3-pyridyl)-1,2,4-triazol-1-yl]-(2-furyl)methanone | cid_971909
Type:
Small organic molecule
Emp. Form.:
C12H9N5O2
Mol. Mass.:
255.2322
SMILES:
Nc1nc(nn1C(=O)c1ccco1)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: