Reaction Details Report a problem with these data
Target
Beta-hexosaminidase subunit beta
Ligand
BDBM40763
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
860±0.0 nM
Citation
 Liu, J; Shikhman, AR; Lotz, MK; Wong, CH Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis. Chem Biol 8:701-11 (2001) [PubMed]  Article 
Target
Name:
Beta-hexosaminidase subunit beta
Synonyms:
Beta-N-acetylhexosaminidase subunit beta | Beta-hexosaminidase subunit beta | Beta-hexosaminidase subunit beta (Hex B) | HEXB | HEXB_HUMAN | Hexosaminidase subunit B
Type:
Enzyme
Mol. Mass.:
63112.58
Organism:
Homo sapiens (Human)
Description:
P07686
Residue:
556
Sequence:
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLLVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNHENM
  
Inhibitor
Name:
BDBM40763
Synonyms:
Iminocyclitol, 6
Type:
Small organic molecule
Emp. Form.:
C9H18N2O4
Mol. Mass.:
218.2502
SMILES:
CN1CC(NC(C)=O)C(O)C(O)C1CO
Structure:
Search PDB for entries with ligand similarity: