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Target
Heat shock 70 kDa protein 1A
Ligand
BDBM31701
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70
IC50
>100000±0 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HSPA1A | Heat Shock 70kDa Protein 1 | V9GZ37_HUMAN | heat shock 70kDa protein 1A
Type:
ATP-binding protein
Mol. Mass.:
51937.99
Organism:
Homo sapiens (Human)
Description:
gi_123271505; GST-tagged ATPase domain
Residue:
476
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM31701
Synonyms:
3-(2-furanyl)-N-(3-methoxypropyl)-3-[(4-methylphenyl)sulfonylamino]propanamide | 3-(2-furyl)-N-(3-methoxypropyl)-3-(tosylamino)propionamide | 3-(2-furyl)-N-(3-methoxypropyl)-3-{[(4-methylphenyl)sulfonyl]amino}propanamide | 3-(furan-2-yl)-N-(3-methoxypropyl)-3-[(4-methylphenyl)sulfonylamino]propanamide | MLS000047323 | SMR000033334 | cid_3239172
Type:
Small organic molecule
Emp. Form.:
C18H24N2O5S
Mol. Mass.:
380.459
SMILES:
COCCCNC(=O)CC(NS(=O)(=O)c1ccc(C)cc1)c1ccco1
Structure:
Search PDB for entries with ligand similarity: