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Target
Heat shock 70 kDa protein 1A
Ligand
BDBM31702
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70
IC50
>100000±0 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HSPA1A | Heat Shock 70kDa Protein 1 | V9GZ37_HUMAN | heat shock 70kDa protein 1A
Type:
ATP-binding protein
Mol. Mass.:
51937.99
Organism:
Homo sapiens (Human)
Description:
gi_123271505; GST-tagged ATPase domain
Residue:
476
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM31702
Synonyms:
1-[2-(2-chloro-6-fluoro-phenyl)acetyl]isonipecotic acid ethyl ester | 1-[2-(2-chloro-6-fluorophenyl)-1-oxoethyl]-4-piperidinecarboxylic acid ethyl ester | MLS000065077 | SMR000078473 | cid_1094120 | ethyl 1-[(2-chloro-6-fluorophenyl)acetyl]-4-piperidinecarboxylate | ethyl 1-[2-(2-chloranyl-6-fluoranyl-phenyl)ethanoyl]piperidine-4-carboxylate | ethyl 1-[2-(2-chloro-6-fluorophenyl)acetyl]piperidine-4-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H19ClFNO3
Mol. Mass.:
327.778
SMILES:
CCOC(=O)C1CCN(CC1)C(=O)Cc1c(F)cccc1Cl
Structure:
Search PDB for entries with ligand similarity: