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Target
Heat shock 70 kDa protein 1A
Ligand
BDBM31718
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70
IC50
>100000±0 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HSPA1A | Heat Shock 70kDa Protein 1 | V9GZ37_HUMAN | heat shock 70kDa protein 1A
Type:
ATP-binding protein
Mol. Mass.:
51937.99
Organism:
Homo sapiens (Human)
Description:
gi_123271505; GST-tagged ATPase domain
Residue:
476
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM31718
Synonyms:
2-[[1-oxo-2-[[1-oxo-2-(1-oxo-2-isoquinolinyl)ethyl]amino]ethyl]amino]acetic acid ethyl ester | 2-[[2-[[2-(1-keto-2-isoquinolyl)acetyl]amino]acetyl]amino]acetic acid ethyl ester | MLS000519883 | SMR000130298 | cid_9551519 | ethyl 2-[2-[2-(1-oxidanylideneisoquinolin-2-yl)ethanoylamino]ethanoylamino]ethanoate | ethyl 2-[[2-[[2-(1-oxoisoquinolin-2-yl)acetyl]amino]acetyl]amino]acetate
Type:
Small organic molecule
Emp. Form.:
C17H19N3O5
Mol. Mass.:
345.3499
SMILES:
CCOC(=O)CNC(=O)CNC(=O)Cn1ccc2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: