Reaction Details Report a problem with these data
Target
Heat shock 70 kDa protein 1A
Ligand
BDBM41999
Substrate
n/a
Meas. Tech.
In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study
IC50
578±43 nM
Citation
 PubChem, PC In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HSPA1A | Heat Shock 70kDa Protein 1 | V9GZ37_HUMAN | heat shock 70kDa protein 1A
Type:
ATP-binding protein
Mol. Mass.:
51937.99
Organism:
Homo sapiens (Human)
Description:
gi_123271505; GST-tagged ATPase domain
Residue:
476
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM41999
Synonyms:
3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic acid | 3-(3,4,5-trihydroxy-6-oxo-9-xanthenyl)propanoic acid | 3-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)propanoic acid | 3-[3,4,5-tris(oxidanyl)-6-oxidanylidene-xanthen-9-yl]propanoic acid | MLS-0111617.0001 | cid_274127
Type:
Small organic molecule
Emp. Form.:
C16H12O7
Mol. Mass.:
316.2623
SMILES:
OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Structure:
Search PDB for entries with ligand similarity: