Reaction Details Report a problem with these data
Target
Lysosomal acid glucosylceramidase
Ligand
BDBM37614
Substrate
n/a
Meas. Tech.
Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50
>50000±n/a nM
Citation
 PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID] 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:
Enzyme
Mol. Mass.:
59724.64
Organism:
Homo sapiens (Human)
Description:
The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:
536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM37614
Synonyms:
(4E)-4-[(2,5-dimethylphenyl)-hydroxy-methylene]-1-(3-imidazol-1-ylpropyl)-5-(4-pyridyl)pyrrolidine-2,3-quinone | (4E)-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione | (4E)-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-1-[3-(1-imidazolyl)propyl]-5-pyridin-4-ylpyrrolidine-2,3-dione | (4E)-4-[(2,5-dimethylphenyl)-oxidanyl-methylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-yl-pyrrolidine-2,3-dione | 4-(2,5-Dimethyl-benzoyl)-3-hydroxy-1-(3-imidazol-1-yl-propyl)-5-pyridin-4-yl-1,5-dihydro-pyrrol-2-one | MLS000033888 | SMR000013600 | cid_5769015
Type:
Small organic molecule
Emp. Form.:
C24H24N4O3
Mol. Mass.:
416.4724
SMILES:
Cc1ccc(C)c(c1)C(=O)C1C(N(CCCn2ccnc2)C(=O)C1=O)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: