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Target
Cell division control protein 42 homolog
Ligand
BDBM43226
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
43870±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43226
Synonyms:
1,1,4,4-tetraketo-N,6-diphenyl-2,3-dihydro-1,4-dithiin-5-carboxamide | 1,1,4,4-tetrakis(oxidanylidene)-N,6-diphenyl-2,3-dihydro-1,4-dithiine-5-carboxamide | 1,1,4,4-tetraoxo-N,6-diphenyl-2,3-dihydro-1,4-dithiin-5-carboxamide | 1,1,4,4-tetraoxo-N,6-diphenyl-2,3-dihydro-1,4-dithiine-5-carboxamide | MLS000728201 | N,3-diphenyl-5,6-dihydro-1,4-dithiine-2-carboxamide 1,1,4,4-tetraoxide | SMR000306894 | cid_1271299
Type:
Small organic molecule
Emp. Form.:
C17H15NO5S2
Mol. Mass.:
377.435
SMILES:
O=C(Nc1ccccc1)C1=C(c2ccccc2)S(=O)(=O)CCS1(=O)=O |c:10|
Structure:
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