Reaction Details Report a problem with these data
Target
Wee1-like protein kinase
Ligand
BDBM43763
Substrate
n/a
Meas. Tech.
Dose Response Cell-based Assay for Inhibitors of Wee1 Degradation
EC50
>49750±n/a nM
Citation
 PubChem, PC Dose Response Cell-based Assay for Inhibitors of Wee1 Degradation PubChem Bioassay (2008)[AID] 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM43763
Synonyms:
4,5-Dimethoxy-1H-indole-2-carboxylic acid [1-(2,3-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide | MLS000332076 | N-[(2,3-dimethoxybenzylidene)amino]-4,5-dimethoxy-1H-indole-2-carboxamide | N-[(2,3-dimethoxyphenyl)methylideneamino]-4,5-dimethoxy-1H-indole-2-carboxamide | SMR000221624 | cid_1963601
Type:
Small organic molecule
Emp. Form.:
C20H21N3O5
Mol. Mass.:
383.3978
SMILES:
COc1cccc(C=NNC(=O)c2cc3c(OC)c(OC)ccc3[nH]2)c1OC |w:8.8|
Structure:
Search PDB for entries with ligand similarity: