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Target
G2/mitotic-specific cyclin-B1
Ligand
BDBM43754
Substrate
n/a
Meas. Tech.
Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation
EC50
>49750±n/a nM
Citation
 PubChem, PC Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation PubChem Bioassay (2008)[AID] 
Target
Name:
G2/mitotic-specific cyclin-B1
Synonyms:
CCNB | CCNB1 | CCNB1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
48340.95
Organism:
Homo sapiens (Human)
Description:
P14635
Residue:
433
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
  
Inhibitor
Name:
BDBM43754
Synonyms:
4-(2-p-phenetylquinoline-4-carbonyl)piperazine-1-carboxylic acid ethyl ester | 4-[[2-(4-ethoxyphenyl)-4-quinolinyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester | MLS000046206 | SMR000031817 | cid_3237815 | ethyl 4-[2-(4-ethoxyphenyl)quinolin-4-yl]carbonylpiperazine-1-carboxylate | ethyl 4-[2-(4-ethoxyphenyl)quinoline-4-carbonyl]piperazine-1-carboxylate | ethyl 4-{[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl}piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C25H27N3O4
Mol. Mass.:
433.4996
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)c1cc(nc2ccccc12)-c1ccc(OCC)cc1
Structure:
Search PDB for entries with ligand similarity: