Reaction Details Report a problem with these data
Target
G2/mitotic-specific cyclin-B1
Ligand
BDBM40850
Substrate
n/a
Meas. Tech.
Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation
EC50
>49750±n/a nM
Citation
 PubChem, PC Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation PubChem Bioassay (2008)[AID] 
Target
Name:
G2/mitotic-specific cyclin-B1
Synonyms:
CCNB | CCNB1 | CCNB1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
48340.95
Organism:
Homo sapiens (Human)
Description:
P14635
Residue:
433
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
  
Inhibitor
Name:
BDBM40850
Synonyms:
7-(2,3-dimethoxyphenyl)-5-(3-methoxyphenyl)-1,7-dihydro-[1,2,3,4]tetrazolo[1,5-a]pyrimidine | 7-(2,3-dimethoxyphenyl)-5-(3-methoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine | 7-(2,3-dimethoxyphenyl)-5-(3-methoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine | MLS000046934 | SMR000032945 | cid_5771404
Type:
Small organic molecule
Emp. Form.:
C19H19N5O3
Mol. Mass.:
365.3859
SMILES:
COc1cccc(c1)C1=Nc2nnnn2C(C1)c1cccc(OC)c1OC |t:9|
Structure:
Search PDB for entries with ligand similarity: