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Target
G2/mitotic-specific cyclin-B1
Ligand
BDBM43728
Substrate
n/a
Meas. Tech.
Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation
EC50
>49750±n/a nM
Citation
 PubChem, PC Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation PubChem Bioassay (2008)[AID] 
Target
Name:
G2/mitotic-specific cyclin-B1
Synonyms:
CCNB | CCNB1 | CCNB1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
48340.95
Organism:
Homo sapiens (Human)
Description:
P14635
Residue:
433
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
  
Inhibitor
Name:
BDBM43728
Synonyms:
(E)-N-(5-chloranylpyridin-2-yl)-3-phenyl-prop-2-enamide | (E)-N-(5-chloro-2-pyridinyl)-3-phenyl-2-propenamide | (E)-N-(5-chloro-2-pyridyl)-3-phenyl-acrylamide | (E)-N-(5-chloropyridin-2-yl)-3-phenylprop-2-enamide | MLS000684215 | N-(5-chloro-2-pyridinyl)-3-phenylacrylamide | SMR000268017 | cid_691131
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O
Mol. Mass.:
258.703
SMILES:
Clc1ccc(NC(=O)\C=C\c2ccccc2)nc1
Structure:
Search PDB for entries with ligand similarity: