Reaction Details Report a problem with these data
Target
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Ligand
BDBM43862
Substrate
n/a
Meas. Tech.
Competition Assay
pH
7.5±0
Temperature
273.15±n/a K
Ki
3.4e+4± 3e+3 nM
Citation
 Peluso, S; de L Ufret, M; O'Reilly, MK; Imperiali, B Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition. Chem Biol 9:1323-8 (2002) [PubMed]  Article 
Target
Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Synonyms:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | NLT1 | OST1 | OST1_YEAST | Oligosaccharyl transferase (OT) | Oligosaccharyl transferase subunit alpha
Type:
Protein
Mol. Mass.:
54057.61
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P41543
Residue:
476
Sequence:
MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSNAYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTTAPGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNETLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQIQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDIDSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKPLSIACYIFTALMGVFVLKTLNMNVTN
  
Inhibitor
Name:
BDBM43862
Synonyms:
2-(aminocarbonylamino)-N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-methylsulfanyl-butanamide | 2-(carbamoylamino)-N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-(methylthio)butanamide | 2-(carbamoylamino)-N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-methylsulfanylbutanamide | Glycopeptide, 3 | MLS000774035 | N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-(methylthio)-2-ureido-butyramide | SMR000365182 | cid_3930725
Type:
Peptide
Emp. Form.:
C19H24N4O5S2
Mol. Mass.:
452.548
SMILES:
COc1ccc(NS(=O)(=O)c2ccc(NC(=O)C(CCSC)NC(N)=O)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: