Reaction Details Report a problem with these data
Target
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Ligand
BDBM43863
Substrate
n/a
Meas. Tech.
Competition Assay
pH
7.5±0
Temperature
273.15±n/a K
Ki
1.1e+3± 5 nM
Citation
 Peluso, S; de L Ufret, M; O'Reilly, MK; Imperiali, B Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition. Chem Biol 9:1323-8 (2002) [PubMed]  Article 
Target
Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Synonyms:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | NLT1 | OST1 | OST1_YEAST | Oligosaccharyl transferase (OT) | Oligosaccharyl transferase subunit alpha
Type:
Protein
Mol. Mass.:
54057.61
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P41543
Residue:
476
Sequence:
MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSNAYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTTAPGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNETLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQIQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDIDSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKPLSIACYIFTALMGVFVLKTLNMNVTN
  
Inhibitor
Name:
BDBM43863
Synonyms:
3-[[4-amino-6-(2,5-dimethoxyanilino)-5-nitro-pyrimidin-2-yl]amino]propyl-dimethyl-amine | 4-N-(2,5-dimethoxyphenyl)-2-N-[3-(dimethylamino)propyl]-5-nitropyrimidine-2,4,6-triamine | Glycopeptide, 3a | MLS000333423 | N'-(2,5-Dimethoxy-phenyl)-N-(3-dimethylamino-propyl)-5-nitro-pyrimidine-2,4,6-triamine | N4-(2,5-dimethoxyphenyl)-N2-[3-(dimethylamino)propyl]-5-nitro-pyrimidine-2,4,6-triamine | N4-(2,5-dimethoxyphenyl)-N2-[3-(dimethylamino)propyl]-5-nitropyrimidine-2,4,6-triamine | SMR000436735 | cid_3642542
Type:
Peptide
Emp. Form.:
C17H25N7O4
Mol. Mass.:
391.4249
SMILES:
COc1ccc(OC)c(Nc2nc(NCCCN(C)C)nc(N)c2[N+]([O-])=O)c1
Structure:
Search PDB for entries with ligand similarity: