Reaction Details Report a problem with these data
Target
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Ligand
BDBM43865
Substrate
n/a
Meas. Tech.
Competition Assay
pH
7.5±0
Temperature
273.15±n/a K
Ki
62± 5 nM
Citation
 Peluso, S; de L Ufret, M; O'Reilly, MK; Imperiali, B Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition. Chem Biol 9:1323-8 (2002) [PubMed]  Article 
Target
Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Synonyms:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | NLT1 | OST1 | OST1_YEAST | Oligosaccharyl transferase (OT) | Oligosaccharyl transferase subunit alpha
Type:
Protein
Mol. Mass.:
54057.61
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P41543
Residue:
476
Sequence:
MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSNAYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTTAPGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNETLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQIQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDIDSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKPLSIACYIFTALMGVFVLKTLNMNVTN
  
Inhibitor
Name:
BDBM43865
Synonyms:
6-formyl-4,7-dihydroxy-9-keto-5H-phenazine-1-carboxylic acid methyl ester | 6-formyl-4,7-dihydroxy-9-oxo-5H-phenazine-1-carboxylic acid methyl ester | Glycopeptide, 4 | Lomofungin | MLS000766240 | SMR000528852 | cid_5351222 | methyl 6-formyl-4,7-dihydroxy-9-oxo-5H-phenazine-1-carboxylate | methyl 6-methanoyl-4,7-bis(oxidanyl)-9-oxidanylidene-5H-phenazine-1-carboxylate
Type:
Peptide
Emp. Form.:
C15H10N2O6
Mol. Mass.:
314.2497
SMILES:
COC(=O)c1ccc(O)c2nc3c(C=O)c(O)cc(O)c3nc12
Structure:
Search PDB for entries with ligand similarity: