Reaction Details Report a problem with these data
Target
Tumor necrosis factor ligand superfamily member 10
Ligand
BDBM44374
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells.
IC50
683±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells. PubChem Bioassay (2009)[AID] 
Target
Name:
Tumor necrosis factor ligand superfamily member 10
Synonyms:
APO2L | TNF10_HUMAN | TNFSF10 | TRAIL | tumor necrosis factor (ligand) superfamily, member 10
Type:
PROTEIN
Mol. Mass.:
32511.55
Organism:
Homo sapiens (Human)
Description:
EBI_101343
Residue:
281
Sequence:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
  
Inhibitor
Name:
BDBM44374
Synonyms:
2-(dichloromethyl)-4-(methylthio)-6-(4-nitrophenyl)-1,3,5-triazine | 2-(dichloromethyl)-4-(methylthio)-6-(4-nitrophenyl)-s-triazine | 2-(dichloromethyl)-4-methylsulfanyl-6-(4-nitrophenyl)-1,3,5-triazine | 2-[bis(chloranyl)methyl]-4-methylsulfanyl-6-(4-nitrophenyl)-1,3,5-triazine | MLS-0390926.0001 | cid_1204674
Type:
Small organic molecule
Emp. Form.:
C11H8Cl2N4O2S
Mol. Mass.:
331.178
SMILES:
CSc1nc(nc(n1)-c1ccc(cc1)[N+]([O-])=O)C(Cl)Cl
Structure:
Search PDB for entries with ligand similarity: