Reaction Details Report a problem with these data
Target
Heat shock cognate 71 kDa protein
Ligand
BDBM31745
Substrate
n/a
Meas. Tech.
In Vitro Hsc70 Dose Response Fluorescence Polarization Assay
IC50
115000±4440 nM
Citation
 PubChem, PC In Vitro Hsc70 Dose Response Fluorescence Polarization Assay PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock cognate 71 kDa protein
Synonyms:
HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70887.67
Organism:
Homo sapiens (Human)
Description:
gi_5729877
Residue:
646
Sequence:
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
  
Inhibitor
Name:
BDBM31745
Synonyms:
8-(2-carbomethoxyphenoxy)carbonyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 8-(2-methoxycarbonylphenoxy)carbonyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 8-[(2-methoxycarbonylphenoxy)-oxomethyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | MLS-0091961.0001 | cid_2930528
Type:
Small organic molecule
Emp. Form.:
C22H19NO6
Mol. Mass.:
393.3894
SMILES:
COC(=O)c1ccccc1OC(=O)c1ccc2NC(C3CC=CC3c2c1)C(O)=O |c:22|
Structure:
Search PDB for entries with ligand similarity: