Reaction Details Report a problem with these data
Target
Heat shock cognate 71 kDa protein
Ligand
BDBM41998
Substrate
n/a
Meas. Tech.
In Vitro Hsc70 Dose Response Fluorescence Polarization Assay
IC50
2730±150 nM
Citation
 PubChem, PC In Vitro Hsc70 Dose Response Fluorescence Polarization Assay PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock cognate 71 kDa protein
Synonyms:
HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70887.67
Organism:
Homo sapiens (Human)
Description:
gi_5729877
Residue:
646
Sequence:
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
  
Inhibitor
Name:
BDBM41998
Synonyms:
(9Z)-9-(3,3-dihydroxyprop-2-enylidene)-5,6-dihydroxy-xanthene-3,4-quinone | (9Z)-9-(3,3-dihydroxyprop-2-enylidene)-5,6-dihydroxyxanthene-3,4-dione | (9Z)-9-[3,3-bis(oxidanyl)prop-2-enylidene]-5,6-bis(oxidanyl)xanthene-3,4-dione | MLS-0111616.0001 | cid_5351983
Type:
Small organic molecule
Emp. Form.:
C16H10O7
Mol. Mass.:
314.2464
SMILES:
OC(=O)C=Cc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Structure:
Search PDB for entries with ligand similarity: