Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM31063
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
20800±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM31063
Synonyms:
2-(methylsulfonyl)-4-phenyl-6-(trifluoromethyl)pyrimidine | 2-mesyl-4-phenyl-6-(trifluoromethyl)pyrimidine | 2-methylsulfonyl-4-phenyl-6-(trifluoromethyl)pyrimidine | MLS000044644 | SMR000022588 | cid_3236803
Type:
Small organic molecule
Emp. Form.:
C12H9F3N2O2S
Mol. Mass.:
302.272
SMILES:
CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccccc1
Structure:
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