Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43539
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
>55700±n/a nM
Citation
PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM43539
Synonyms:
(2R,3R,4S)-2-ethoxy-4-(4-ethynylphenyl)-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid allyl ester | (2R,3R,4S)-2-ethoxy-4-(4-ethynylphenyl)-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid prop-2-enyl ester | (2R,3R,4S)-allyl 2-ethoxy-4-(4-ethynylphenyl)-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylate | MLS000766370 | SMR000389513 | cid_16195760 | prop-2-enyl (2R,3R,4S)-2-ethoxy-4-(4-ethynylphenyl)-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylate | prop-2-enyl (2R,3R,4S)-2-ethoxy-4-(4-ethynylphenyl)-3-(3-oxidanylpropyl)-3,4-dihydro-2H-pyran-6-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H26O5
Mol. Mass.:
370.4388
SMILES:
CCO[C@@H]1OC(=C[C@@H]([C@H]1CCCO)c1ccc(cc1)C#C)C(=O)OCC=C |c:5|
Structure:
