Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM37357
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
>29900±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM37357
Synonyms:
1-(1-tert-butyl-1,2,3,4-tetrazol-5-yl)-1-(4-fluorophenyl)-N-(furan-2-ylmethyl)-N-[(3-methoxyphenyl)methyl]methanamine | 1-(1-tert-butyl-5-tetrazolyl)-1-(4-fluorophenyl)-N-(2-furanylmethyl)-N-[(3-methoxyphenyl)methyl]methanamine | 1-(1-tert-butyltetrazol-5-yl)-1-(4-fluorophenyl)-N-(furan-2-ylmethyl)-N-[(3-methoxyphenyl)methyl]methanamine | MLS000030271 | SMR000004019 | [(1-tert-Butyl-1H-tetrazol-5-yl)-(4-fluoro-phenyl)-methyl]-furan-2-ylmethyl-(3-methoxy-benzyl)-amine | [(1-tert-butyltetrazol-5-yl)-(4-fluorophenyl)methyl]-(2-furfuryl)-m-anisyl-amine | cid_648894
Type:
Small organic molecule
Emp. Form.:
C25H28FN5O2
Mol. Mass.:
449.5205
SMILES:
COc1cccc(CN(Cc2ccco2)C(c2nnnn2C(C)(C)C)c2ccc(F)cc2)c1
Structure:
Search PDB for entries with ligand similarity: