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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM47968
Substrate
n/a
Meas. Tech.
Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90)
IC50
1612±n/a nM
Citation
 PubChem, PC Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) PubChem Bioassay (2009)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM47968
Synonyms:
MLS000686315 | N-[4-({(4Z)-1-oxo-4-[(thien-2-ylsulfonyl)imino]-1,4-dihydronaphthalen-2-yl}amino)phenyl]acetamide | N-[4-[(1-oxidanylidene-4-thiophen-2-ylsulfonylimino-naphthalen-2-yl)amino]phenyl]ethanamide | N-[4-[(1-oxo-4-thiophen-2-ylsulfonylimino-2-naphthalenyl)amino]phenyl]acetamide | N-[4-[(1-oxo-4-thiophen-2-ylsulfonyliminonaphthalen-2-yl)amino]phenyl]acetamide | N-[4-[[(4Z)-1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]phenyl]acetamide | N-[4-[[1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]phenyl]acetamide | SMR000313158 | cid_3715121
Type:
Small organic molecule
Emp. Form.:
C22H17N3O4S2
Mol. Mass.:
451.518
SMILES:
CC(=O)Nc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)cc1 |w:12.12,t:9|
Structure:
Search PDB for entries with ligand similarity: