Reaction Details Report a problem with these data
Target
Matrix metalloproteinase-14 [1-36]
Ligand
BDBM48125
Substrate
n/a
Meas. Tech.
Luminescent HTS for small molecule inhibitors of MT1-MMP transcription
EC50
50000±n/a nM
Citation
 PubChem, PC Luminescent HTS for small molecule inhibitors of MT1-MMP transcription PubChem Bioassay (2008)[AID] 
Target
Name:
Matrix metalloproteinase-14 [1-36]
Synonyms:
MMP14 | MMP14_PONAB | matrix metalloproteinase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
3658.23
Organism:
Homo sapiens (Human)
Description:
gi_6690534
Residue:
36
Sequence:
MSPAPRPSRCLLLPLLTLGTALASLGSAQSSSFSPE
  
Inhibitor
Name:
BDBM48125
Synonyms:
2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-6-ethyl-3-(furan-2-ylmethyl)thieno[2,3-d]pyrimidin-4-one | 2-[(3,5-dimethyl-4-isoxazolyl)methylthio]-6-ethyl-3-(2-furanylmethyl)-4-thieno[2,3-d]pyrimidinone | 2-[(3,5-dimethylisoxazol-4-yl)methylthio]-6-ethyl-3-(2-furfuryl)thieno[2,3-d]pyrimidin-4-one | MLS000098667 | SMR000068699 | cid_2571817
Type:
Small organic molecule
Emp. Form.:
C19H19N3O3S2
Mol. Mass.:
401.502
SMILES:
CCc1cc2c(nc(SCc3c(C)noc3C)n(Cc3ccco3)c2=O)s1
Structure:
Search PDB for entries with ligand similarity: